Main Role
- Ninomiya KazunariAmagi YukihikoMain Role
Support Role
- Takeuchi RyomaSera MasashiSupport Role
- Aoi WakanaHanabusa MiwaSupport Role
- Koizumi KotaroTakashina GontaSupport Role
- Uchino SeiyouSaeki SeigoSupport Role
- ShuriNekota MariSupport Role
- Danta YasunoriSugai TatsuoSupport Role
- Hashimoto SatoshiKurosaki SeiichiroSupport Role
- Kanno MisuzuFujiwara MakotoSupport Role
- Uchimura HarukaKakitani YujiSupport Role
- Konno HirokiSekikawa FuminoriSupport Role
- Kim Mu JunPark Min JaeSupport Role
- Tanaka MinamiShiina MisakiSupport Role
- Morita KanroTaguchi KoheiSupport Role
- Yamada YusukeHayami KoichiSupport Role
- Matsukawa NarukiKitajima TatsuyaSupport Role
- Mizutani KahoMiyamoto AyumiSupport Role
- Ishizaka KojiShingyoji RyutaroSupport Role
Guest Role
- Choi Ji WooPark So Hyeon (Ep. 1, 5)Guest Role
- Ian MooreCedric Morin (Ep. 1)Guest Role
- Shirahige ZenPark Min Jae [Young] (Ep. 1)Guest Role
- Hayama Yuki[Medical intern] (Ep. 1)Guest Role
- Nakamura Ryoji(Ep. 1)Guest Role
- Makoto NaoyaShigeno Takamichi (Ep. 2)Guest Role
- Niiro ShinyaYasujima Kyoya (Ep. 2)Guest Role
- Shoji HanaeKajitani Toshiko (Ep. 3)Guest Role
- Tatekawa DanshunKajitani Takatoshi [Toshiko's son] (Ep. 3)Guest Role
- Umezawa TomioMizuno Yuichi (Ep. 3)Guest Role
- Hanafusa MariTojima Kazuko [Miwa's mother] (Ep. 4-5)Guest Role
- Ikeda TetsuhiroNoda Yoshiyuki [Ishin University doctor] (Ep. 4-6)Guest Role
- Kato KojiIkenaga Hideto (Ep. 4, 7)Guest Role
- Megumi ToshiakiKizaki Daigo (Ep. 5)Guest Role
- Han Sung Min[Casino dealer] (Ep. 5)Guest Role
- Zaiki Takuma[Investigator with arrest warrant] (Ep. 5)Guest Role
- Sakai MasaakiUesugi Toshikazu (Ep. 6-7)Guest Role
- Takiuchi KumiHayakawa Reiko [Ishin University doctor] (Ep. 6)Guest Role
- Doronzu Ishimoto[Restaurant chef] (Rp. 6)Guest Role
- Ito Momoka[Nurse during Nekota's time in Ishin] (Ep. 6)Guest Role
- Shirota YuUesugi Toshihiro [Toshikazu's son] (Ep. 7)Guest Role
- Kudo ShunsakuPresident Wang (Ep. 7)Guest Role
- Ohguro MakiEjiri Norie [Deputy director of Tojo University Hospital] (Ep. 7-10)Guest Role
- Matsuki Kenya[MC at Japan Medical Association election] (Ep. 7)Guest Role
- Ohno Mizuki[Toshikazu's secretary] (Ep. 7)Guest Role
- Fukuzawa AkiraTomizawa Masayuki [Ministry of Health staff] (Ep. 8)Guest Role
- Owada ShinyaAmagi Tsukasa (Ep. 8-10)Guest Role
- Nagano Yukiko[Caretaker of Tokai residence] (Ep. 8)Guest Role
- Yaegashi Yuta(Ep. 8)Guest Role
- Miyajima Haruka[Operating room nurse] (Ep. 8-9)Guest Role
- Iwashita HisafumiYamamura Hiroyuki [Doctor at Fujimi Clinic] (Ep. 9)Guest Role
- Inoue HajimeTokunaga Eiichi (Ep. 9-10)Guest Role
- Tsuji KazunagaTokai Ichiro (Ep. 9)Guest Role
- Takemoto Kenshi[MC at Tojo University director election] (Ep. 9)Guest Role
- Cynthia Cheston[Yukihiko's adoptive mother] (Ep. 9)Guest Role
- Gamo Junichi[MC at International Heart Surgeon Conference] (Ep. 9-10)Guest Role
- Satsuki Emi[Cerisier Heart Center nurse] (Ep. 11)Guest Role
Voice Actor
- Mitsuishi KotonoElcano | Elcano IIVoice Actor
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