1 Litre of Tears, for me at least i literally cried at least 1 litres of tears, if not more, watching this.
If you haven't cried in every episode after episode 2 then something is wrong with you, in my opinion at least.
It is also a very good Japanese drama to watch, highly rated, good actors with good if not great acting and the plot is amazing.
I honestly can't watch it again because it was that good if not great since it was that sad to watch, if you get what i mean?