ML can't tolerate it if the FL leaves him or tries to leave him, or if someone tries to separate him from her. Because he loves her so much.
Dramas like this that I have already watched:
Secret Garden (he fell ill when he was separated from her)
Our Beloved Summer (he fell ill, developed insomnia and was a total depressed mess when she left him)
Beauty and Mr Romantic (the SML here was like that)
Love Like the Galaxy (he had no will to live after she left him)