I have not watched many animes and it seems you seen pretty much all I could think of but one.
Cross Game << Very good baseball anime. Touch is also another good one by the same guy with more episodes but its like 20 years older.
Ie Naki Ko is a really good anime it's based on the book Sans Famille. It's about a boy named Remi who lives in a small town in France with his Mother while his father works in Paris. His father is injured at work and comes and ask his mother why she's still keeping an orphan boy around and to get rid of him. He learns that his mother isn't his real mother and she refuses to put Remi out and the next day his adoptive father sells him to a traveling entertainer named Vitalis for 40 Franks. Remi then travels around France with Vitalis and his troupe that includes 2 dogs and a monkey. I posted a link the opening one the saddest op's in an anime.