Tearjerkers

ML vanishes/dies?

FL dies

FL is terminally ill

the leads separate

FL becomes mentally ill and trapped in her life

the leads separate

ML dies protecting the pregnant FL, she raises their daughter alone

FL dies

ML is either dead or critically wounded at the end, it's unclear

ML dies

ML dies

one of the MLs dies, other is terminally ill

ML dies

ML dies

FL dies

the leads are separated by time (FL returns to the present, ML remains in the past)

the leads are separated by different timelines/possibly a time loop in which ML dies at the end

almost all the characters die

the leads are separated by dimensions

the leads are separated (FL returns to the real world, ML remains in the fictional one)

ML has only a brief time left to live

ML dies

ML dies

ML is terminally ill, all three leads appear still as lost at the end as at the beginning

the leads separate (FL returns to the real world, ML remains in the novel)

FL dies, ML is prevented from adopting/raising her child who he was attached to

FL dies

ML dies

FL dies

leads break up

FL and supporting characters die

leads are separated by time and space

FL dies

FL dies

both leads die

both leads die

the leads are separated by time (FL returns to the present, ML remains in the past)

bittersweet/happy ending for the leads, almost everyone else dies

both MLs appear to die in the end

FL dies/disappears

FL dies

FL dies after much tragedy

ML dies

ML dies

the leads separate

the leads are separated (FL returns to her parallel world, ML remains in his)

FL dies

FL dies (possibly ML as well, it's unclear)

ML dies

ML dies

leads separate

FL dies

FL dies

FL dies

ML dies

ML dies

one of the FLs dies

one of the MLs dies

ML dies

ML has only a few years left to live

leads are separated

FL dies

the leads separate

FL dies

the leads separate (it appears one may die) 

FL dies

ML dies

ML dies

ML dies