It's been a couple of years since I last watched it but I'll try and tell you what I remember.
Something among the main characters in High School wrecks their friendship. They go their separate ways and then reunite as adults when the He Hao Yi starts to work at the same company as the Ai Li Si.
At some time after High School, Ai Li Si undergoes surgery for something serious and a side effect/complication is that she (temporarily) looses some of her memories. I can't remember if it was an illness or an accident that caused her to have surgery. As the show goes on, He Hao Yi tries to get Ai Li Si to "unlock" those memories and the 2nd ML tries to stop him.